About doravirine
Non-nucleoside reverse transcriptase inhibitor combination
Used for
- Treats HIV-1 infection with two other HIV medicines in eligible patients.
Usual adult dose
One tablet by mouth once daily, with or without food; combination contains doravirine, lamivudine, and tenofovir disoproxil fumarate.
Common side effects
- Dizziness
- Nausea
- Diarrhea
- Abnormal dreams or sleep problems
Important warnings
- Not recommended for people with certain kidney or liver problems.
- Do not stop treatment without medical supervision; HIV may become resistant.
- May cause immune reconstitution syndrome after starting treatment.
- Not suitable when HIV resistance or treatment history makes its components ineffective.
Pregnancy
Human pregnancy information is limited; treatment choice should consider current HIV pregnancy guidance.
Breastfeeding
People with HIV are generally advised not to breastfeed, to prevent HIV transmission.
Interactions
- Rifampin, rifapentine, and St John’s wort can reduce doravirine levels; avoid use.
- Carbamazepine, oxcarbazepine, phenobarbital, and phenytoin can reduce doravirine levels; avoid use.
- Strong enzyme-inducing medicines may reduce effectiveness; check before combining.
- Other medicines affecting kidney function may increase risk from tenofovir.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.