About donepezil
Acetylcholinesterase inhibitor
Used for
- Treats symptoms of mild to severe Alzheimer’s disease.
- May help with memory, thinking, and daily functioning; it does not cure Alzheimer’s.
Usual adult dose
Usually 5 mg once daily, often at bedtime. A prescriber may increase to 10 mg after at least 4–6 weeks; higher doses may be used for severe disease.
Common side effects
- Nausea, diarrhea, or vomiting
- Loss of appetite or weight loss
- Insomnia or vivid dreams
- Muscle cramps, dizziness, or fainting
Important warnings
- Can slow the heartbeat and cause fainting, especially with existing heart rhythm problems.
- May increase stomach acid and risk of ulcers or bleeding.
- Tell clinicians before surgery; it can affect anesthesia medicines.
- Use caution with asthma, seizures, urinary blockage, or liver problems.
Pregnancy
There is limited information about use in pregnancy; it is generally used only when a clinician considers it necessary.
Breastfeeding
It is not known whether donepezil passes into human milk; breastfeeding use requires clinical assessment.
Interactions
- Anticholinergic medicines may reduce donepezil’s effects.
- Some medicines, including ketoconazole and fluoxetine, may increase donepezil levels.
- NSAIDs such as ibuprofen may increase stomach bleeding risk.
- Other medicines that slow heart rate can increase fainting or rhythm risks.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.