About domperido ne
Peripheral dopamine antagonist; prokinetic and antiemetic
Used for
- Relief of nausea and vomiting
- Short-term treatment of symptoms from delayed stomach emptying
Usual adult dose
Usually 10 mg up to three times daily, before meals; use the lowest effective dose for the shortest time.
Common side effects
- Dry mouth
- Headache or dizziness
- Abdominal cramps or diarrhoea
- Raised prolactin, causing breast symptoms or menstrual changes
Important warnings
- Can cause serious abnormal heart rhythms, especially at higher doses or with risk factors.
- Avoid with certain heart-rhythm medicines, strong CYP3A4 inhibitors, or significant liver disease.
- Use is restricted in some countries; follow local product guidance.
- Seek urgent care for fainting or a fast, irregular heartbeat.
Pregnancy
Generally avoided unless a clinician considers it necessary; human safety information is limited.
Breastfeeding
Passes into breast milk in small amounts; use only if considered necessary, as effects on the infant are uncertain.
Interactions
- Some antibiotics, including clarithromycin and erythromycin, increase heart-rhythm risk.
- Azole antifungals such as ketoconazole can raise domperidone levels.
- Avoid medicines that prolong the QT interval.
- Antacids and acid-reducing medicines may reduce absorption if taken together.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.