About dolutegravir sodium
Integrase strand transfer inhibitor antiretroviral
Used for
- Treats HIV-1 infection with other HIV medicines.
Usual adult dose
Usually 50 mg once daily; some resistance-related situations require 50 mg twice daily.
Usual dose in children
For children weighing at least 20 kg: usually 50 mg once daily; specialist dosing depends on weight and other medicines.
Common side effects
- Headache
- Nausea
- Diarrhea
- Insomnia
Important warnings
- Rarely causes severe allergic reactions or liver problems.
- Can cause mood changes, including depression or suicidal thoughts.
- Separate from supplements containing iron or calcium unless taken with food.
- Do not stop HIV treatment without medical guidance.
Pregnancy
Use with other HIV medicines. Current evidence supports use during pregnancy; treatment should be reviewed by an HIV specialist.
Breastfeeding
Breastfeeding is generally not recommended for people with HIV where safe alternatives are available; follow local guidance.
Interactions
- Rifampin and certain seizure medicines can lower dolutegravir levels.
- Antacids and supplements containing magnesium or aluminum reduce absorption.
- Metformin levels may increase; dose adjustment or monitoring may be needed.
- Do not use with dofetilide.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.