About dofetilide
Class III antiarrhythmic
Used for
- Maintaining normal heart rhythm in people with atrial fibrillation or flutter.
- Converting atrial fibrillation or flutter to normal rhythm.
Usual adult dose
Usually 500 micrograms twice daily; kidney function and ECG results determine the dose. Initiated in hospital.
Common side effects
- Headache
- Dizziness
- Chest pain
- Dangerous abnormal heart rhythms, including torsades de pointes
Important warnings
- Requires hospital monitoring when starting or restarting treatment.
- Dose depends on kidney function and QT interval on ECG.
- Seek urgent care for fainting or a rapid, irregular heartbeat.
- Do not stop or restart without medical supervision.
Pregnancy
Human pregnancy data are limited; use only when clearly needed after clinician assessment.
Breastfeeding
It is unknown whether dofetilide passes into breast milk; discuss risks with a clinician.
Interactions
- Do not combine with cimetidine, verapamil, ketoconazole, trimethoprim, or hydrochlorothiazide.
- Avoid other medicines that prolong the QT interval when possible.
- Some medicines impair kidney transport and dangerously increase dofetilide levels.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.