About divalproex sodium
Anticonvulsant and mood stabilizer
Used for
- Seizure disorders, including focal and generalized seizures
- Bipolar disorder, especially manic episodes
- Prevention of migraine headaches
Usual adult dose
Seizures: commonly 10–15 mg/kg daily, adjusted gradually. Mania: often 750 mg daily initially. Migraine prevention: often 250 mg twice daily.
Usual dose in children
Seizures: usually 10–15 mg/kg daily, adjusted gradually; specialist dosing depends on age and seizure type.
Common side effects
- Nausea, stomach discomfort, or diarrhea
- Sleepiness, dizziness, or tremor
- Weight gain or hair thinning
- Low platelets or liver injury
Important warnings
- Can cause severe liver injury, especially in young children or people with liver disease.
- Can cause pancreatitis; severe abdominal pain needs urgent assessment.
- May cause birth defects and developmental harm; avoid during pregnancy when possible.
- Do not stop suddenly; blood tests may be needed.
Pregnancy
High risk of birth defects and developmental problems. Avoid for migraine prevention during pregnancy; seizure or bipolar treatment requires specialist review.
Breastfeeding
Small amounts enter breast milk. Breastfeeding is often possible with monitoring for infant sleepiness, poor feeding, or jaundice.
Interactions
- Raises bleeding risk with aspirin or warfarin.
- Carbapenem antibiotics can sharply lower valproate levels.
- May increase lamotrigine levels and serious rash risk.
- Alcohol and sedatives can worsen drowsiness.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.