About distigmine
Long-acting acetylcholinesterase inhibitor
Used for
- Treatment of underactive bladder and difficulty emptying the bladder.
- Treatment of myasthenia gravis in some countries.
Usual adult dose
Bladder problems: commonly 5 mg once daily; dosing varies by country and indication.
Common side effects
- Diarrhea, nausea, abdominal cramps, and increased saliva or sweating.
- Slow heartbeat, muscle cramps, weakness, or muscle twitching.
- Blurred vision and increased urination.
Important warnings
- Overdose can cause severe weakness, breathing problems, or a dangerously slow heartbeat.
- Avoid in bowel or urinary obstruction and when the intestinal tract is not moving.
- Use cautiously with asthma, heart rhythm problems, or low blood pressure.
- Treatment and dose require medical supervision.
Pregnancy
Limited information; use only when a clinician considers it necessary.
Breastfeeding
Limited information; effects on a breastfed infant are uncertain.
Interactions
- Other cholinesterase inhibitors can increase adverse effects.
- Anticholinergic medicines, including atropine, may reduce its effects.
- Succinylcholine effects may be prolonged.
- Beta-blockers can increase the risk of a slow heartbeat.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.