About disodium clodronate
Bisphosphonate bone resorption inhibitor
Used for
- Treats high blood calcium caused by cancer.
- Helps prevent bone complications in some cancers affecting bones.
- Treats bone loss associated with certain cancers.
Usual adult dose
Commonly 1,600 mg daily by mouth, as one dose or divided; the dose varies by condition and kidney function.
Common side effects
- Diarrhoea, nausea, or vomiting.
- Stomach pain.
- Raised liver enzymes.
- Low blood calcium.
Important warnings
- Take with water on an empty stomach; separate from food and other medicines as directed.
- Swallow capsules whole; do not lie down immediately after taking.
- Kidney problems may require dose adjustment and monitoring.
- Seek urgent care for severe muscle cramps, tingling, or spasms, which may indicate low calcium.
Pregnancy
Avoid during pregnancy unless a specialist considers it essential; human safety information is limited.
Breastfeeding
Breastfeeding is generally not recommended during treatment because effects on infants are uncertain.
Interactions
- Calcium, iron, magnesium, and antacids can reduce absorption; separate doses.
- Other bisphosphonates may increase adverse effects.
- Non-steroidal anti-inflammatory drugs may increase kidney injury risk.
- Aminoglycoside antibiotics may increase the risk of low blood calcium.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.