About disodium clodronat e
Bisphosphonate bone-resorption inhibitor
Used for
- Treats high blood calcium caused by cancer.
- Helps prevent bone complications in some cancers affecting bones.
- Treats certain bone disorders, including Paget disease.
Usual adult dose
Often 1,600 mg daily for cancer-related bone disease; dosing varies by condition and country.
Common side effects
- Diarrhea, nausea, or stomach discomfort.
- Low blood calcium or phosphate.
- Kidney problems.
- Rarely, jawbone damage or unusual thigh-bone fractures.
Important warnings
- Follow the prescribed dose; excessive use can cause serious harm.
- Kidney function and blood calcium may need monitoring.
- Take with water on an empty stomach; avoid food and minerals around dosing.
- Report new jaw pain or persistent thigh or groin pain.
Pregnancy
Avoid during pregnancy unless a specialist determines it is essential; human safety information is limited.
Breastfeeding
Breastfeeding is generally not recommended during treatment; discuss alternatives with a clinician.
Interactions
- Calcium, iron, magnesium, and antacids reduce absorption; separate doses.
- Nonsteroidal anti-inflammatory drugs may increase kidney risks.
- Other medicines affecting kidney function may increase kidney risks.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.