About dienogest + estradiol valerate
Progestin and estrogen hormone combination
Used for
- Treatment of heavy menstrual bleeding in women without organic pathology.
- Hormone therapy for menopausal symptoms, depending on the product’s licensed use.
Usual adult dose
Regimens vary by indication and tablet sequence; follow the product leaflet. Typical heavy-bleeding treatment uses a 28-day sequence.
Common side effects
- Headache or migraine
- Nausea, abdominal pain, or breast tenderness
- Irregular bleeding or spotting
- Mood changes
Important warnings
- Can increase blood-clot risk; risk is higher with smoking, age, or immobility.
- Avoid with current or past blood clots, certain cancers, or unexplained vaginal bleeding.
- Seek urgent care for chest pain, sudden breathlessness, or one-sided leg swelling.
- Product indications and schedules vary by country; check the local leaflet.
Pregnancy
Not for use during pregnancy. Stop and seek medical advice if pregnancy occurs.
Breastfeeding
Generally not recommended during breastfeeding; estrogen can reduce milk supply.
Interactions
- Some seizure medicines, rifampicin, and St John’s wort may reduce hormone levels.
- Some HIV or hepatitis medicines can alter hormone levels.
- May affect blood-glucose control in people with diabetes.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.