About diclofenac sodium + misoprostol
NSAID with prostaglandin analogue
Used for
- Relieves osteoarthritis and rheumatoid arthritis pain and inflammation.
- Helps reduce NSAID-related stomach ulcers in people needing diclofenac.
Usual adult dose
One tablet by mouth two or three times daily with food, as prescribed.
Common side effects
- Diarrhea, abdominal pain, nausea, or indigestion.
- Headache, dizziness, or fluid retention.
- Stomach or intestinal ulceration, bleeding, or perforation.
- Raised liver enzymes or kidney problems.
Important warnings
- Can cause serious gastrointestinal bleeding, ulcers, or perforation.
- Increases risk of heart attack and stroke, especially with prolonged use.
- Avoid during pregnancy; misoprostol can cause miscarriage, premature labor, or birth defects.
- Use caution with heart, kidney, liver, or bleeding problems.
Pregnancy
Contraindicated in pregnancy because misoprostol can cause miscarriage and serious fetal harm; diclofenac also carries fetal risks.
Breastfeeding
Diclofenac and misoprostol enter breast milk; use is generally not recommended while breastfeeding.
Interactions
- Blood thinners and antiplatelet medicines increase bleeding risk.
- Other NSAIDs or aspirin increase gastrointestinal and cardiovascular risks.
- ACE inhibitors, ARBs, and diuretics may worsen kidney function.
- Lithium and methotrexate levels may rise.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.