About denosumab
RANK ligand inhibitor; monoclonal antibody
Used for
- Treats osteoporosis in people at high fracture risk.
- Prevents bone loss from certain hormone treatments or long-term corticosteroid use.
- Treats bone loss in some people receiving prostate or breast cancer treatment.
Usual adult dose
60 mg injected under the skin every 6 months.
Common side effects
- Back, joint, or muscle pain
- High cholesterol
- Skin rash or eczema
- Low blood calcium
Important warnings
- Low calcium can be severe; risk is higher with kidney disease.
- Rare jawbone problems and unusual thigh fractures can occur.
- Stopping or delaying treatment can cause rapid bone loss and spinal fractures.
- Serious infections and severe allergic reactions are possible.
Pregnancy
Not recommended during pregnancy; may harm an unborn baby. Effective contraception is advised during treatment and for at least 5 months after the last dose.
Breastfeeding
It is unknown whether denosumab passes into breast milk; discuss risks and benefits with a healthcare professional.
Interactions
- Other denosumab products increase the risk of serious side effects.
- Medicines that lower calcium may increase the risk of low blood calcium.
- Tell clinicians about medicines affecting the immune system.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.