About demeclocycline
Tetracycline antibiotic
Used for
- Certain bacterial infections, including respiratory and skin infections
- Sometimes used for syndrome of inappropriate antidiuretic hormone secretion (SIADH)
Usual adult dose
Infections: usually 150 mg every 6 hours or 300 mg every 12 hours. SIADH dosing is specialist-directed.
Usual dose in children
For children aged 8 years and older, dosing is weight-based and prescribed by a clinician; generally avoided in younger children.
Common side effects
- Nausea, vomiting, diarrhea, or stomach discomfort
- Sun sensitivity and skin rash
- Tooth discoloration or effects on developing bones
- Kidney problems, including excessive urination and thirst
Important warnings
- Not suitable for viral infections; unnecessary use promotes antibiotic resistance.
- Avoid during pregnancy and generally in children younger than 8 years.
- Can cause sun sensitivity; prolonged use may affect kidney function.
- Seek urgent care for severe allergic reaction or severe, persistent diarrhea.
Pregnancy
Generally avoid; tetracyclines can affect fetal bone and tooth development, particularly later in pregnancy.
Breastfeeding
Use is generally avoided or limited; ask a clinician because infant effects and exposure depend on treatment duration.
Interactions
- Antacids, iron, calcium, magnesium, and zinc can reduce absorption.
- May increase anticoagulant effects of warfarin.
- May reduce effectiveness of some penicillin antibiotics.
- Retinoids such as isotretinoin may increase risk of raised pressure around the brain.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.