About dasabuvir
Direct-acting antiviral; NS5B polymerase inhibitor
Used for
- Treats chronic hepatitis C genotype 1, with other antiviral medicines.
Usual adult dose
250 mg twice daily with food, alongside ombitasvir/paritaprevir/ritonavir, with or without ribavirin; treatment duration depends on patient factors.
Common side effects
- Fatigue
- Nausea
- Itching
- Trouble sleeping
Important warnings
- Never use alone; combine with prescribed hepatitis C medicines.
- Not used for hepatitis C genotypes other than genotype 1.
- Can reactivate hepatitis B; screening is needed before treatment.
- Liver injury has occurred with combination treatment, especially in people with advanced liver disease.
Pregnancy
Pregnancy risks depend partly on accompanying medicines. Ribavirin can cause severe birth defects and is contraindicated during pregnancy.
Breastfeeding
Breastfeeding safety is uncertain; accompanying medicines and the underlying condition also affect recommendations.
Interactions
- Rifampin and several seizure medicines can lower treatment effectiveness; avoid combination.
- Some HIV medicines and drugs affecting liver enzymes can cause harmful interactions.
- Hormonal medicines containing ethinylestradiol can increase liver enzyme levels; avoid combination.
- Check all medicines and supplements for interactions before starting treatment.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.