About darunavir + cobicistat
HIV protease inhibitor and pharmacokinetic enhancer
Used for
- Used with other HIV medicines to treat HIV-1 infection in eligible adults.
- Not a complete HIV treatment by itself.
Usual adult dose
One tablet once daily with food, alongside other HIV medicines.
Common side effects
- Diarrhea, nausea, or abdominal pain
- Headache
- Rash
- Changes in liver tests
Important warnings
- Do not use for HIV treatment in children.
- Can cause serious liver problems or severe skin reactions.
- May worsen hepatitis B or C; monitor liver health.
- Many medicines interact; some combinations can cause serious harm or treatment failure.
Pregnancy
Not generally recommended during pregnancy because cobicistat can lower darunavir levels; treatment may need changing.
Breastfeeding
People with HIV are generally advised not to breastfeed where safe alternatives are available; HIV can pass through breast milk.
Interactions
- Rifampin, St. John’s wort, and certain seizure medicines can reduce treatment levels.
- Some cholesterol medicines, sedatives, and heart medicines can reach dangerous levels.
- Do not combine with medicines strongly affected by CYP3A without checking compatibility.
- Antacids and acid-reducing medicines may affect other HIV medicines used alongside it.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.