About darunavir amorphous
HIV protease inhibitor
Used for
- Treatment of HIV-1 infection with other antiretroviral medicines.
Usual adult dose
Usually 600 mg twice daily with ritonavir; some adults take 800 mg once daily with ritonavir, depending on treatment history and resistance.
Usual dose in children
For children aged 3 years and older, dose is based on weight and treatment history, with ritonavir; specialist guidance is required.
Common side effects
- Diarrhea, nausea, vomiting, or abdominal pain
- Rash
- Headache
- Raised blood sugar or cholesterol
Important warnings
- Must be taken with food and a prescribed booster, usually ritonavir or cobicistat.
- Can cause severe skin reactions or liver problems.
- May worsen blood sugar, cholesterol, or bleeding disorders.
- Not suitable for children under 3 years.
Pregnancy
Darunavir may be used during pregnancy with an appropriate booster and other HIV medicines; regimen choice requires specialist guidance.
Breastfeeding
Breastfeeding is generally not recommended for people with HIV where safe alternatives are available.
Interactions
- Many medicines interact, including rifampin, St. John’s wort, and certain seizure medicines.
- Can interact with statins, blood thinners, sedatives, and hormonal contraceptives.
- Ritonavir or cobicistat boosting increases interaction risks.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.