About darunavir
HIV protease inhibitor
Used for
- Treats HIV-1 infection with other antiretroviral medicines.
Usual adult dose
Usually 800 mg once daily with ritonavir or cobicistat and food; dosing depends on resistance and treatment history.
Usual dose in children
For children aged 3 years or older, dosing is weight-based with ritonavir and food; specialist guidance is required.
Common side effects
- Diarrhea, nausea, vomiting, or abdominal pain
- Headache or rash
- Increased liver enzymes
- Raised blood sugar or cholesterol
Important warnings
- Rare severe skin reactions and allergic reactions can occur.
- Liver problems may worsen; monitor for symptoms or abnormal tests.
- May increase bleeding in people with hemophilia.
- Does not prevent HIV transmission; use effective prevention measures.
Pregnancy
Use with other HIV medicines. Pregnancy dosing and monitoring require specialist review; cobicistat-containing regimens may not maintain adequate drug levels.
Breastfeeding
Breastfeeding is generally not recommended with HIV because of transmission risk; follow local HIV guidance.
Interactions
- Many medicines interact, including rifampin, certain seizure medicines, and St John's wort.
- Do not combine with drugs such as simvastatin or oral midazolam.
- Some HIV medicines and anticoagulants require dose adjustment or monitoring.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.