About darunavir
HIV-1 protease inhibitor
Used for
- Treats HIV-1 infection with other antiretroviral medicines.
Usual adult dose
Usually 800 mg once daily with ritonavir or cobicistat and food; some people need 600 mg twice daily.
Usual dose in children
For children aged 3 years and older, dose is based on weight and taken with ritonavir and food.
Common side effects
- Diarrhea, nausea, vomiting, or abdominal pain
- Rash or itching
- Headache
- Raised liver enzymes or cholesterol
Important warnings
- Can cause serious allergic or skin reactions, including rare severe rashes.
- Liver problems may worsen; seek assessment for yellow skin, dark urine, or severe abdominal pain.
- Can raise blood sugar and cholesterol or cause changes in body fat.
- Not suitable for some people with severe liver disease or certain drug interactions.
Pregnancy
Use with other HIV medicines when appropriate; treatment choice and monitoring depend on pregnancy guidance and individual circumstances.
Breastfeeding
HIV can pass through breast milk; breastfeeding recommendations depend on local guidance and individual circumstances.
Interactions
- Many medicines interact, including rifampin, some seizure medicines, and St John’s wort.
- May alter levels of certain statins, blood thinners, sedatives, and erectile dysfunction medicines.
- Acid-reducing medicines can affect treatment; interaction checks are needed.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.