About saxagliptin + dapagliflozin
DPP-4 inhibitor and SGLT2 inhibitor combination
Used for
- Improves blood sugar control in adults with type 2 diabetes, alongside diet and exercise.
Usual adult dose
Usually saxagliptin 5 mg plus dapagliflozin 10 mg once daily; dose may be lower with kidney problems or interacting medicines.
Common side effects
- Genital yeast infections or urinary infections
- Increased urination
- Low blood sugar, especially with insulin or sulfonylureas
- Nausea, headache, or respiratory infections
Important warnings
- Not for type 1 diabetes or diabetic ketoacidosis.
- Rarely causes serious ketoacidosis, even when blood sugar is not very high.
- Can worsen heart failure; seek prompt assessment for new swelling or breathlessness.
- Kidney function, dehydration, and pancreatitis symptoms require clinical attention.
Pregnancy
Generally avoided, especially during the second and third trimesters; discuss alternatives with a clinician.
Breastfeeding
Not recommended because effects on a nursing infant are uncertain and dapagliflozin may affect kidney development.
Interactions
- Strong CYP3A4/5 inhibitors can raise saxagliptin levels and require dose adjustment.
- Insulin or sulfonylureas increase low-blood-sugar risk.
- Diuretics may increase dehydration and low-blood-pressure risk.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.