About dapagliflozin + metformin hcl
SGLT2 inhibitor and biguanide
Used for
- Type 2 diabetes, alongside diet and exercise
- May reduce heart-failure hospitalization risk in eligible adults
- May slow chronic kidney disease progression in eligible adults
Usual adult dose
Usually one tablet twice daily with meals; dose depends on kidney function and prior treatment.
Common side effects
- Genital yeast infections
- Urinary tract infections
- Diarrhea, nausea, or stomach discomfort
- Low blood sugar, especially with insulin or sulfonylureas
Important warnings
- Avoid in type 1 diabetes or diabetic ketoacidosis.
- Kidney function must be checked; unsuitable with severe impairment.
- Risk of dehydration, low blood pressure, and rare ketoacidosis.
- Stop temporarily for certain surgery, prolonged fasting, or serious illness.
Pregnancy
Not recommended, particularly during the second and third trimesters; metformin use requires clinician review.
Breastfeeding
Generally not recommended because dapagliflozin may affect the nursing infant; seek clinician guidance.
Interactions
- Insulin or sulfonylureas increase low blood sugar risk.
- Diuretics can increase dehydration and low blood pressure.
- Some medicines affecting kidney function or metformin clearance increase adverse-effect risk.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.