About dantrolene sodium
Direct-acting skeletal muscle relaxant
Used for
- Treats malignant hyperthermia, a rare emergency reaction to anesthesia.
Usual adult dose
Malignant hyperthermia: 2.5 mg/kg intravenously; repeat as needed, guided by response and maximum dosing guidance.
Usual dose in children
Malignant hyperthermia: 2.5 mg/kg intravenously; repeat as needed, guided by response and maximum dosing guidance.
Common side effects
- Muscle weakness
- Drowsiness or dizziness
- Nausea or vomiting
- Injection-site reactions
Important warnings
- For intravenous use in malignant hyperthermia; requires urgent specialist care.
- May cause muscle weakness and impaired breathing.
- Use caution with liver disease or other medicines that can harm the liver.
- Rapid intravenous administration may cause serious heart or blood vessel problems.
Pregnancy
Use when clearly needed; emergency treatment of malignant hyperthermia may be lifesaving.
Breastfeeding
Breastfeeding safety after intravenous treatment is not well established; seek specialist guidance.
Interactions
- Calcium-channel blockers, especially verapamil, may cause dangerous heart problems.
- Muscle relaxants and sedatives can increase weakness or breathing problems.
- Other medicines that harm the liver may increase liver injury risk.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.