About danazol
Synthetic androgen and gonadotropin suppressant
Used for
- Endometriosis
- Fibrocystic breast disease
- Hereditary angioedema prevention
Usual adult dose
Endometriosis: usually 200–800 mg daily in divided doses. Breast disease: usually 100–400 mg daily. Hereditary angioedema: individualized, lowest effective dose.
Common side effects
- Weight gain, acne, oily skin, increased facial or body hair
- Voice deepening or menstrual changes
- Hot flushes, sweating, mood changes
- Liver enzyme changes; rarely serious liver problems
Important warnings
- Can cause irreversible voice changes and other masculinizing effects.
- Avoid in pregnancy; treatment can harm a developing fetus.
- May cause blood clots, liver problems, or increased blood pressure.
- Not suitable for people with certain cancers or unexplained vaginal bleeding.
Pregnancy
Contraindicated. Danazol can harm the fetus and may cause masculinization; pregnancy should be excluded before treatment.
Breastfeeding
Avoid during breastfeeding; safety is not established and hormonal effects may harm the infant.
Interactions
- Warfarin: danazol can increase anticoagulant effects and bleeding risk.
- Statins, especially simvastatin: increased risk of muscle injury.
- Cyclosporine or tacrolimus: blood levels may rise.
- Diabetes medicines: danazol may alter blood glucose control.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.