About dacomitinib
EGFR tyrosine kinase inhibitor
Used for
- Treats certain advanced non-small-cell lung cancers with EGFR mutations.
Usual adult dose
45 mg by mouth once daily, until disease progression or unacceptable side effects.
Common side effects
- Diarrhea
- Skin rash and inflammation
- Mouth sores
- Nail inflammation
Important warnings
- Diarrhea can cause dehydration and kidney problems.
- Severe skin reactions and lung inflammation can occur.
- May cause liver problems; liver tests are monitored.
- Avoid grapefruit and St. John’s wort.
Pregnancy
May harm an unborn baby. Pregnancy should be avoided during treatment and for at least 17 days afterward.
Breastfeeding
Breastfeeding is not recommended during treatment and for at least 17 days after the final dose.
Interactions
- Acid-reducing medicines can lower dacomitinib absorption.
- Strong CYP2D6 inhibitors may increase side effects.
- Grapefruit and St. John’s wort can alter drug levels.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.