About cyproterone acetate + estradiol
Antiandrogen and estrogen hormone therapy
Used for
- Hormone replacement therapy for estrogen deficiency after menopause
- Relief of menopausal symptoms, including hot flushes
- Treatment of androgen-related symptoms such as acne or excess hair in selected women
Usual adult dose
Usually one tablet daily for 21 days, followed by a 7-day break; follow the prescribed pack schedule.
Common side effects
- Headache, nausea, abdominal discomfort
- Breast tenderness or irregular bleeding
- Mood changes or reduced sexual interest
- Fluid retention or weight changes
Important warnings
- Increases risk of blood clots, stroke, and some cancers; risk depends on individual factors.
- Not a contraceptive; pregnancy must be avoided during treatment.
- Avoid with current or previous blood clots, severe liver disease, or hormone-sensitive cancers.
- Seek urgent care for sudden chest pain, breathlessness, one-sided leg swelling, or neurological symptoms.
Pregnancy
Do not use during pregnancy; stop and seek medical advice if pregnancy occurs.
Breastfeeding
Generally not recommended during breastfeeding; it can affect milk production and infant exposure.
Interactions
- Some seizure, tuberculosis, and HIV medicines can reduce hormone effectiveness.
- St John’s wort may reduce effectiveness and cause irregular bleeding.
- Some antifungals, antibiotics, and grapefruit may increase hormone levels.
- May affect medicines such as anticoagulants and diabetes treatments; monitoring may be needed.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.