About conjugated estrogen + medroxyprogesterone acetate
Estrogen-progestin hormone replacement therapy
Used for
- Relief of moderate to severe menopause-related hot flashes and night sweats
- Prevention of osteoporosis after menopause when other options are unsuitable
Usual adult dose
Usually one tablet by mouth once daily, taken continuously.
Common side effects
- Breast tenderness or pain
- Headache
- Nausea or abdominal discomfort
- Vaginal spotting or bleeding
Important warnings
- Can increase risks of blood clots, stroke, heart attack, and certain cancers.
- Unexplained vaginal bleeding requires evaluation before treatment.
- Not for preventing heart disease or dementia.
- Use the lowest effective dose for the shortest necessary duration.
Pregnancy
Not used during pregnancy; discontinue if pregnancy occurs.
Breastfeeding
Generally not recommended while breastfeeding; estrogen can reduce milk production.
Interactions
- Enzyme-inducing medicines such as rifampin, carbamazepine, and St John’s wort may reduce hormone levels.
- Some seizure medicines may reduce effectiveness.
- Thyroid replacement needs may change; monitoring may be required.
- May affect blood clotting medicines such as warfarin.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.