About collagenase clostridium histolyticum
Enzyme that breaks down collagen
Used for
- Dupuytren’s contracture in adults
- Peyronie’s disease in adult men
Usual adult dose
Dupuytren’s: 0.58 mg injected into each cord per treatment. Peyronie’s: 0.58 mg injected per treatment; dosing occurs in treatment cycles.
Common side effects
- Swelling, bruising, pain, or bleeding at injection site
- Skin tears or blisters
- Hand pain or swelling
- Penile bruising, swelling, or pain
Important warnings
- Rare serious allergic reactions can occur.
- Dupuytren’s treatment can cause tendon, ligament, or nerve injury.
- Peyronie’s treatment can cause penile fracture or other serious injury.
- Only trained healthcare professionals should inject this medicine.
Pregnancy
Not indicated for pregnancy; effects on an unborn baby are unknown.
Breastfeeding
Unknown whether it passes into breast milk; use is not indicated during breastfeeding.
Interactions
- Blood thinners may increase bruising or bleeding.
- Recent use of other collagenase products may increase side effects.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.