About cloxacillin sodium
Penicillinase-resistant penicillin antibiotic
Used for
- Treats infections caused by susceptible staphylococci, including skin, bone, and bloodstream infections.
Usual adult dose
Typically 1–2 g intravenously every 4–6 hours; dose depends on infection and local guidance.
Usual dose in children
Typically 25–50 mg/kg intravenously every 6 hours; severe infections may require higher doses.
Common side effects
- Nausea, vomiting, or diarrhea
- Rash or allergic reactions
- Injection-site pain or inflammation
- Rarely, liver or kidney problems
Important warnings
- Avoid with a serious allergy to penicillins or cephalosporins.
- Seek urgent care for breathing difficulty, facial swelling, or severe rash.
- Use only for susceptible bacterial infections; unnecessary use promotes resistance.
- Dose adjustment and monitoring may be needed with kidney or liver problems.
Pregnancy
Generally considered usable when clinically needed; available evidence has not shown a clear increase in birth defects.
Breastfeeding
Usually compatible; small amounts may enter milk and occasionally cause infant diarrhea or thrush.
Interactions
- Probenecid can increase cloxacillin levels.
- Methotrexate toxicity may increase.
- Warfarin effects may change; monitoring may be needed.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.