About clomipramine hydrochloride
Tricyclic antidepressant
Used for
- Obsessive-compulsive disorder
- Depression
- Panic disorder
Usual adult dose
Usually starts at 25 mg daily, increasing gradually. Typical maintenance is 100–250 mg daily, depending on condition.
Usual dose in children
For OCD, ages 10 and older: start 25 mg daily; increase gradually. Maximum 200 mg daily or 3 mg/kg, whichever is lower.
Common side effects
- Dry mouth, constipation, blurred vision
- Drowsiness, dizziness, sweating
- Weight gain, tremor, sexual problems
- Fast heartbeat or low blood pressure
Important warnings
- May increase suicidal thoughts, especially early in treatment or after dose changes.
- Do not stop suddenly; withdrawal symptoms can occur.
- Can cause abnormal heart rhythms, seizures, or serotonin syndrome.
- Use caution with bipolar disorder, glaucoma, urinary problems, or heart disease.
Pregnancy
Use only when clearly needed; treatment decisions should weigh maternal benefits against possible pregnancy and newborn risks.
Breastfeeding
Clomipramine enters breast milk. Infant exposure and effects should be assessed with a healthcare professional.
Interactions
- MAO inhibitors: risk of dangerous reactions; avoid within 14 days.
- Serotonergic medicines, including some antidepressants and tramadol: serotonin syndrome risk.
- Medicines affecting heart rhythm or clomipramine levels may increase serious side effects.
- Alcohol and sedatives can worsen drowsiness and impaired coordination.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.