About clodronate
Bisphosphonate bone-resorption inhibitor
Used for
- Treats high blood calcium caused by cancer
- Helps prevent bone damage in some cancers
- Treats osteoporosis or other bone disorders in some countries
Usual adult dose
Often 1,600–2,400 mg daily for cancer-related high blood calcium; dosing varies by condition and country.
Common side effects
- Diarrhea, nausea, or stomach discomfort
- Low blood calcium
- Muscle or bone pain
- Rarely, jawbone damage or unusual thigh-bone fractures
Important warnings
- Take capsules with water on an empty stomach; follow product-specific instructions.
- Separate from food, milk, and mineral supplements, which can reduce absorption.
- Kidney problems may require dose adjustment; kidney function is monitored.
- Seek assessment for severe diarrhea, jaw pain, or persistent thigh or groin pain.
Pregnancy
Avoid during pregnancy unless a specialist considers it essential; pregnancy safety is not established.
Breastfeeding
Breastfeeding is generally not recommended during treatment because effects on the infant are uncertain.
Interactions
- Calcium, iron, magnesium, antacids, and dairy reduce absorption.
- Other medicines affecting the kidneys may increase kidney-related risks.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.