About clobazam
Benzodiazepine anticonvulsant
Used for
- Add-on treatment for seizures, especially Lennox–Gastaut syndrome
- Short-term treatment of severe anxiety in some countries
Usual adult dose
Seizures: usually 5–40 mg daily, adjusted gradually; anxiety dosing varies by country and product.
Usual dose in children
Seizures: usually 5 mg daily initially, adjusted gradually by weight and response; specialist supervision is needed.
Common side effects
- Sleepiness and dizziness
- Tiredness or poor coordination
- Drooling or constipation
- Dependence and withdrawal symptoms
Important warnings
- Can slow breathing, especially with opioids, alcohol, or other sedatives.
- Long-term use may cause tolerance and dependence; stopping suddenly can trigger seizures.
- May impair alertness and coordination; avoid driving if affected.
- Use extra caution with breathing problems, liver disease, or a history of substance misuse.
Pregnancy
May harm the unborn baby, especially late in pregnancy; use only when a clinician judges benefits outweigh risks.
Breastfeeding
Clobazam enters breast milk and may cause infant sleepiness or poor feeding; breastfeeding requires clinical assessment.
Interactions
- Opioids, alcohol, and sedatives increase drowsiness and breathing problems.
- CYP2C19 inhibitors, such as omeprazole or fluconazole, may raise active metabolite levels.
- Carbamazepine, phenytoin, or rifampicin may alter clobazam levels.
- Clobazam can increase levels of some medicines, including omeprazole and dextromethorphan.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.