About amoxicillin + clavulanate
Penicillin antibiotic with beta-lactamase inhibitor
Used for
- Treats susceptible bacterial infections, including severe respiratory, urinary, skin, bone, and joint infections.
- Used to prevent infections during some surgeries.
Usual adult dose
Commonly 1.2 g intravenously every 8 hours; some severe infections require every 6 hours. Adjust for kidney function.
Usual dose in children
Children aged 3 months and older: commonly 30 mg/kg intravenously every 8 hours; severe infections may require every 6 hours. Dosing depends on age, weight, and kidney function.
Common side effects
- Diarrhea, nausea, or vomiting
- Rash or itching
- Injection-site discomfort or vein inflammation
- Liver enzyme changes; rarely, serious liver injury
Important warnings
- Do not use with serious allergy to penicillins or other beta-lactam antibiotics.
- Seek urgent care for breathing difficulty, facial swelling, or a severe skin reaction.
- Antibiotic-associated diarrhea can be severe and may occur after treatment ends.
- Use caution with liver disease; kidney impairment may require dose adjustment.
Pregnancy
May be used when clinically needed; the prescriber should weigh benefits and risks.
Breastfeeding
Generally compatible; monitor the infant for diarrhea, rash, or thrush.
Interactions
- Warfarin and related anticoagulants: may alter clotting; monitoring may be needed.
- Allopurinol: may increase the chance of skin rash.
- Probenecid: may increase and prolong amoxicillin levels.
- Mycophenolate: may reduce levels of its active form.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.