About cinacalcet hcl
Calcimimetic agent
Used for
- Treats high parathyroid hormone levels in adults with chronic kidney disease receiving dialysis.
- Treats high calcium levels caused by parathyroid cancer.
- Treats high calcium levels from primary hyperparathyroidism when surgery is unsuitable or unsuccessful.
Usual adult dose
Usually started at 30 mg once daily for dialysis-related hyperparathyroidism; other uses have different starting doses and titration schedules.
Usual dose in children
For dialysis-related hyperparathyroidism in children aged 3 years and older, dosing is based on weight and specialist monitoring.
Common side effects
- Nausea and vomiting
- Diarrhea
- Low blood calcium
- Dizziness or muscle aches
Important warnings
- Low calcium can cause tingling, cramps, seizures, or abnormal heart rhythm.
- Calcium levels require monitoring, especially after starting or changing the dose.
- Use cautiously with seizure history or heart-rhythm problems.
- Do not use for children with parathyroid cancer or primary hyperparathyroidism.
Pregnancy
Human pregnancy information is limited; use only when a clinician considers it necessary.
Breastfeeding
It is unknown whether cinacalcet passes into human milk; discuss treatment and feeding with a clinician.
Interactions
- Strong CYP3A4 inhibitors, such as ketoconazole, can increase cinacalcet levels.
- Cinacalcet may increase levels of CYP2D6 medicines, including some antidepressants and beta blockers.
- Etelcalcetide: concurrent use may increase the risk of low calcium.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.