About cinacalcet hcl
Calcimimetic calcium-lowering medicine
Used for
- Treats high calcium from parathyroid cancer.
- Treats high parathyroid hormone in adults receiving dialysis for chronic kidney disease.
- Treats high calcium from primary hyperparathyroidism when surgery is unsuitable.
Usual adult dose
Usually starts at 30 mg once daily for dialysis-related hyperparathyroidism; doses are adjusted using blood tests. Other conditions require individualized dosing.
Usual dose in children
For children aged 3 years or older on dialysis, dosing is weight-based and guided by blood tests.
Common side effects
- Nausea and vomiting
- Diarrhea
- Muscle aches
- Low blood calcium
Important warnings
- Can cause dangerously low blood calcium, including seizures or heart rhythm problems.
- Blood calcium should be checked before and during treatment.
- Do not start if blood calcium is below normal.
- Seek urgent care for tingling, cramps, spasms, or seizures.
Pregnancy
Limited information; use only when the expected benefit outweighs potential risk.
Breastfeeding
It is unknown whether cinacalcet passes into breast milk; discuss risks with a healthcare professional.
Interactions
- Strong CYP3A4 inhibitors, such as ketoconazole, can increase cinacalcet levels.
- Cinacalcet can increase metoprolol levels.
- Other medicines lowering blood calcium may increase the risk of hypocalcemia.
- Cinacalcet may alter levels of CYP2D6 medicines, including some antidepressants and heart medicines.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.