About cilostazol
Phosphodiesterase-3 inhibitor; antiplatelet and vasodilator
Used for
- Improves walking distance in adults with intermittent claudication from peripheral arterial disease.
Usual adult dose
100 mg by mouth twice daily, at least 30 minutes before or 2 hours after meals. Reduce to 50 mg twice daily with certain interacting medicines.
Common side effects
- Headache
- Diarrhea or abnormal stools
- Palpitations
- Dizziness
Important warnings
- Do not use in heart failure of any severity.
- May increase bleeding risk; use caution with bleeding disorders or other blood-thinning medicines.
- Avoid grapefruit; it can increase cilostazol levels.
- Cilostazol may be unsuitable with certain strong enzyme-inhibiting medicines.
Pregnancy
Human pregnancy data are limited; use only when clearly needed after clinician assessment.
Breastfeeding
Unknown whether cilostazol passes into breast milk; breastfeeding safety is not established.
Interactions
- Strong CYP3A4 or CYP2C19 inhibitors can raise levels; dose reduction may be needed.
- Aspirin, clopidogrel, and anticoagulants may increase bleeding risk.
- Grapefruit may increase cilostazol levels.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.