About cilastatin sodium + imipenem
Carbapenem antibiotic combination
Used for
- Treats serious bacterial infections, including infections of the lungs, abdomen, urinary tract, skin, bones, and blood.
- Used for certain infections caused by susceptible bacteria.
Usual adult dose
Usually 500 mg of each ingredient intravenously every 6 hours; dose depends on infection and kidney function.
Usual dose in children
For children aged 3 months or older, usually 15–25 mg/kg of imipenem every 6 hours; specialist dosing is required.
Common side effects
- Nausea, vomiting, or diarrhea
- Rash or itching
- Pain or inflammation at the injection site
- Seizures, especially with kidney problems or high doses
Important warnings
- Use only for bacterial infections; it does not treat viral illnesses.
- Dose adjustment is needed for impaired kidney function.
- Seizure risk is higher with kidney impairment or brain disorders.
- Serious allergic reactions, severe diarrhea, or blood-cell abnormalities can occur.
Pregnancy
Use during pregnancy only when clearly needed; available human safety information is limited.
Breastfeeding
Small amounts may enter breast milk; monitor the infant for diarrhea or thrush.
Interactions
- Valproic acid or divalproex: levels may fall, increasing seizure risk.
- Ganciclovir: may increase seizure risk.
- Warfarin: antibiotic treatment may alter blood-clotting test results.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.