About cyclosporine
Calcineurin inhibitor immunosuppressant
Used for
- Prevention of organ transplant rejection
- Treatment of severe rheumatoid arthritis
- Treatment of severe psoriasis
Usual adult dose
Varies by condition, transplant, and blood levels; commonly 2.5–15 mg/kg daily in divided doses.
Usual dose in children
For transplant rejection prevention, commonly 6–15 mg/kg daily in divided doses; specialist-directed.
Common side effects
- High blood pressure
- Kidney problems
- Tremor or headache
- Increased infection risk
Important warnings
- Requires regular blood tests and monitoring of kidney function and blood pressure.
- Do not switch brands or formulations without prescriber supervision.
- Avoid grapefruit and grapefruit juice.
- Serious infections and some cancers may occur with long-term treatment.
Pregnancy
May be used when necessary under specialist care; risks and benefits should be reviewed.
Breastfeeding
Usually avoided because ciclosporin passes into breast milk; specialist advice is essential.
Interactions
- Many medicines affect ciclosporin levels, including some antibiotics and antifungals.
- NSAIDs can increase kidney injury risk.
- Potassium supplements and potassium-sparing diuretics may raise blood potassium.
- St John’s wort can lower ciclosporin levels.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.