About chloroquine phosphate
Antimalarial; antiprotozoal
Used for
- Treatment and prevention of malaria where parasites remain chloroquine-sensitive.
- Treatment of extraintestinal amoebiasis, usually with another medicine.
Usual adult dose
Varies by infection and region; malaria treatment commonly totals 1,500 mg chloroquine base over three days. Prevention commonly uses 300 mg base once weekly.
Usual dose in children
For malaria, dosing is weight-based and depends on the regimen and local resistance; prevention is also weight-based.
Common side effects
- Nausea, stomach cramps, diarrhea, or headache
- Itching or skin rash
- Blurred vision or other eye problems with prolonged use
- Rarely, heart rhythm problems, seizures, or severe blood disorders
Important warnings
- Chloroquine-resistant malaria is widespread; use only where sensitive parasites are expected.
- Long-term or high-dose use can damage the retina; eye monitoring may be needed.
- Can affect heart rhythm, especially with heart disease or interacting medicines.
- Overdose can be rapidly fatal, particularly in children; keep securely stored.
Pregnancy
May be used for malaria prevention or treatment when indicated; choice depends on destination and parasite sensitivity.
Breastfeeding
Small amounts enter breast milk; breastfeeding alone does not protect an infant from malaria.
Interactions
- Medicines that prolong heart rhythm, including some antibiotics and antipsychotics
- Antacids and kaolin can reduce absorption; separate doses by several hours.
- Cimetidine may increase chloroquine levels.
- Digoxin or cyclosporine levels may rise.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.