About chlorambu cil
Alkylating chemotherapy medicine
Used for
- Chronic lymphocytic leukaemia
- Hodgkin lymphoma
- Some non-Hodgkin lymphomas
- Waldenström macroglobulinaemia
Usual adult dose
Dose varies by cancer and treatment plan; commonly 0.1–0.2 mg/kg by mouth daily for a limited course.
Usual dose in children
Specialist-directed dosing varies by cancer and body weight.
Common side effects
- Low blood cell counts, increasing infection or bleeding risk
- Nausea, vomiting, or diarrhoea
- Mouth sores
- Infertility
Important warnings
- Can cause serious bone-marrow suppression and infection.
- May increase risk of later cancers and blood disorders.
- Can harm an unborn baby; effective contraception is important.
- Requires specialist supervision and regular blood tests.
Pregnancy
Avoid during pregnancy; chlorambucil can harm the developing baby.
Breastfeeding
Breastfeeding is not recommended during treatment.
Interactions
- Other medicines that suppress bone marrow may increase blood-count problems.
- Live vaccines may cause infection in people with weakened immunity.
- Tell the cancer team about all medicines and supplements.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.