About ceritinib free base
ALK inhibitor anticancer medicine
Used for
- Treats ALK-positive advanced non-small-cell lung cancer.
Usual adult dose
450 mg by mouth once daily with food; dose may be adjusted for side effects.
Common side effects
- Diarrhea, nausea, vomiting, or abdominal pain
- Raised liver enzymes
- High blood sugar
- Slow heart rate or abnormal heart rhythm
Important warnings
- Can cause serious liver injury; liver tests are monitored.
- Can cause severe gastrointestinal problems, pancreatitis, or lung inflammation.
- May prolong the QT interval or slow the heart rate.
- Avoid grapefruit and grapefruit juice; many medicines interact.
Pregnancy
May harm an unborn baby. Effective contraception is recommended during treatment and for 6 months afterward.
Breastfeeding
Do not breastfeed during treatment and for 2 weeks after the last dose.
Interactions
- Strong CYP3A inhibitors can raise ceritinib levels.
- Strong CYP3A inducers can lower ceritinib levels.
- Ceritinib can affect levels of CYP3A and CYP2C9 medicines.
- Medicines that prolong QT can increase abnormal heart rhythm risk.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.