About celecoxib ph eur
COX-2 selective nonsteroidal anti-inflammatory drug
Used for
- Osteoarthritis and rheumatoid arthritis pain and inflammation
- Ankylosing spondylitis
- Short-term acute pain
- Painful menstrual periods
Usual adult dose
Usually 200 mg daily for osteoarthritis; other conditions commonly use 200–400 mg daily, divided if needed.
Usual dose in children
For juvenile rheumatoid arthritis, ages 2 years and older: 50 mg twice daily if under 25 kg; 100 mg twice daily if 25 kg or more.
Common side effects
- Indigestion, abdominal pain, diarrhea, or nausea
- Headache or dizziness
- Fluid retention and raised blood pressure
- Serious stomach bleeding, kidney problems, or allergic reactions
Important warnings
- Can increase risk of heart attack or stroke, especially with higher doses or prolonged use.
- May cause stomach ulcers or bleeding, even without warning symptoms.
- Avoid with sulfonamide allergy or around coronary artery bypass surgery.
- Use caution with heart, kidney, or liver disease, asthma, or prior stomach ulcers.
Pregnancy
Avoid from 20 weeks unless specifically directed; avoid from about 30 weeks because of fetal heart and kidney risks.
Breastfeeding
Small amounts may enter milk; short-term use is generally considered compatible, but evidence is limited.
Interactions
- Blood thinners, aspirin, and other NSAIDs increase bleeding risk.
- ACE inhibitors, ARBs, and diuretics may increase kidney risks or reduce blood pressure control.
- Fluconazole can raise celecoxib levels; rifampin can lower them.
- Lithium levels may rise; check with prescribed monitoring.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.