About ceftriaxone + sulbactam
Cephalosporin antibiotic plus beta-lactamase inhibitor
Used for
- Treats certain serious bacterial infections, including respiratory, urinary, abdominal, skin, and bloodstream infections.
- May be used for infections caused by susceptible bacteria resistant to some antibiotics.
Usual adult dose
Given by injection or infusion; dosing depends on infection and local guidance. The ceftriaxone component is commonly 1–2 g once daily.
Usual dose in children
Specialist-directed dosing based on weight, age, infection, and product guidance.
Common side effects
- Diarrhea, nausea, or vomiting
- Injection-site pain or inflammation
- Rash or allergic reactions
- Changes in blood counts or liver tests
Important warnings
- Use only for bacterial infections; unnecessary use promotes antibiotic resistance.
- Serious allergy can occur, especially with cephalosporins or penicillins.
- Ceftriaxone can cause gallbladder or kidney deposits, especially with prolonged treatment.
- Not for mixing or simultaneous administration with calcium-containing IV solutions in newborns.
Pregnancy
Ceftriaxone is used during pregnancy when clinically appropriate; evidence for the sulbactam combination is more limited.
Breastfeeding
Ceftriaxone generally has low milk exposure; monitor the infant for diarrhea, thrush, or rash.
Interactions
- Calcium-containing IV solutions: potentially dangerous precipitation, especially in newborns.
- Warfarin: may increase bleeding risk; monitoring may be needed.
- Other antibiotics or medicines affecting kidney function may require clinician review.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.