About ceftazidime + avibactam
Cephalosporin antibiotic plus beta-lactamase inhibitor
Used for
- Serious complicated urinary tract infections, including kidney infections
- Complicated abdominal infections, with additional antibiotic coverage
- Hospital-acquired and ventilator-associated bacterial pneumonia
- Infections caused by certain resistant Gram-negative bacteria
Usual adult dose
2 g/0.5 g intravenously every 8 hours, usually over 2 hours; adjust for kidney function.
Usual dose in children
Children aged 3 months and older: dose by weight and kidney function, intravenously every 8 hours; specialist guidance is required.
Common side effects
- Nausea, vomiting, or diarrhea
- Abdominal pain
- Headache
- Liver enzyme changes
Important warnings
- Use only for susceptible bacterial infections; cultures and resistance testing may guide treatment.
- Dose adjustment is needed with reduced kidney function.
- Serious allergic reactions can occur, especially with cephalosporin or other beta-lactam allergy.
- Antibiotic-associated severe diarrhea and seizures are possible.
Pregnancy
Use during pregnancy only when clearly needed; human pregnancy data are limited.
Breastfeeding
Ceftazidime and avibactam may pass into breast milk; discuss potential infant effects with a clinician.
Interactions
- Probenecid may increase ceftazidime exposure and is generally avoided.
- Kidney function should be monitored with medicines that may affect the kidneys.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.