About cefepime m
Fourth-generation cephalosporin antibiotic
Used for
- Treats complicated urinary tract infections, including kidney infections.
- Treats hospital-acquired and ventilator-associated pneumonia.
- Treats complicated abdominal infections with metronidazole.
- Treats febrile neutropenia in combination with other antibiotics.
Usual adult dose
Usually 2 g cefepime intravenously every 8 hours; dose and duration depend on infection and kidney function.
Usual dose in children
For children 2 months and older: usually 50 mg/kg intravenously every 8–12 hours; maximum 2 g per dose. Depends on infection and kidney function.
Common side effects
- Diarrhea, nausea, or vomiting
- Rash or itching
- Infusion-site reactions
- Confusion or seizures, especially with kidney impairment
Important warnings
- Serious allergic reactions can occur, particularly with penicillin or cephalosporin allergy.
- Kidney impairment requires dose adjustment; accumulation can cause brain-related toxicity.
- Antibiotics can cause severe, persistent diarrhea due to C. difficile.
- Use only for bacterial infections; unnecessary use promotes antibiotic resistance.
Pregnancy
Human pregnancy data are limited. Use when clinically needed; treatment decisions depend on the infection and alternatives.
Breastfeeding
Cefepime passes into breast milk in small amounts. Infant effects are unlikely, but diarrhea or thrush may occur.
Interactions
- Aminoglycosides and potent diuretics may increase kidney-related toxicity.
- Probenecid can increase cefepime levels.
- Anticoagulants may have altered effects; monitoring may be needed.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.