About cefazolin sodium usp
First-generation cephalosporin antibiotic
Used for
- Treats susceptible bacterial infections, including skin, bone, urinary, and bloodstream infections
- Prevents infections during certain surgeries
Usual adult dose
Usually 1–2 g intravenously or intramuscularly every 8 hours; dose depends on infection and kidney function.
Usual dose in children
Usually 25–50 mg/kg/day intravenously or intramuscularly in divided doses every 6–8 hours; severe infections may require higher doses.
Common side effects
- Diarrhea, nausea, or vomiting
- Injection-site pain or inflammation
- Rash or itching
- Rarely, severe allergic reaction or antibiotic-associated colitis
Important warnings
- Avoid with serious allergy to cefazolin or other cephalosporins; discuss severe penicillin allergy.
- Dose adjustment may be needed with impaired kidney function.
- Seek urgent care for breathing difficulty, facial swelling, or severe skin reactions.
- Use only for susceptible bacterial infections; unnecessary use promotes antibiotic resistance.
Pregnancy
Generally considered usable when clinically needed; available evidence has not shown an increased risk of birth defects.
Breastfeeding
Usually compatible; small amounts may enter milk. Infant diarrhea or thrush can occur.
Interactions
- Probenecid may increase cefazolin levels.
- Warfarin may increase bleeding risk; monitoring may be needed.
- Other medicines affecting kidney function may increase kidney-related risks.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.