About cefazolin sodium
First-generation cephalosporin antibiotic
Used for
- Treats susceptible bacterial infections, including skin, bone, urinary, and bloodstream infections.
- Prevents infections during surgery.
Usual adult dose
Usually 0.5–1 g every 6–8 hours; severe infections may need 1–1.5 g every 6 hours. Surgical prevention: 1–2 g before surgery.
Usual dose in children
Usually 25–50 mg/kg daily in divided doses every 6–8 hours; severe infections may need up to 100 mg/kg daily.
Common side effects
- Nausea, vomiting, or diarrhea
- Injection-site pain or inflammation
- Rash or itching
- Rarely, severe allergic reaction or antibiotic-associated colitis
Important warnings
- Dose adjustment may be needed with kidney impairment.
- Serious allergy can occur, especially with previous severe reactions to cephalosporins or penicillins.
- Seek urgent care for severe or bloody diarrhea.
- Use only for bacterial infections; unnecessary use promotes antibiotic resistance.
Pregnancy
Generally considered usable when needed; treatment should be based on clinical assessment.
Breastfeeding
Small amounts may enter breast milk; infant diarrhea or thrush can occur.
Interactions
- Probenecid may increase cefazolin levels.
- Warfarin may increase bleeding risk; monitoring may be needed.
- Other medicines affecting kidney function may increase kidney-related risks.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.