About carglumic acid
Urea-cycle disorder treatment
Used for
- Treats hyperammonaemia in N-acetylglutamate synthase deficiency.
- Treats hyperammonaemia in certain organic acid disorders, including propionic and methylmalonic acidemias.
- May be used for other inherited metabolic disorders causing high blood ammonia.
Usual adult dose
Usually 100–250 mg/kg daily by mouth, divided into 2–4 doses; specialist-adjusted to ammonia levels.
Usual dose in children
Usually 100–250 mg/kg daily by mouth, divided into 2–4 doses; specialist-adjusted to ammonia levels.
Common side effects
- Vomiting
- Fever
- Reduced appetite
- Increased liver enzymes
Important warnings
- Requires specialist supervision and blood-ammonia monitoring.
- Severe hyperammonaemia may need emergency hospital treatment and additional therapies.
- Dose is individualized; follow the prescribed dosing and preparation instructions.
- Avoid use with alcohol dehydrogenase inhibitors such as metronidazole.
Pregnancy
Limited human data; use only when the specialist considers treatment necessary, weighing potential benefits and risks.
Breastfeeding
Limited information; breastfeeding decisions should be made with the treating specialist.
Interactions
- Alcohol dehydrogenase inhibitors, including metronidazole, may reduce carglumic acid breakdown.
- No other well-established clinically important interactions are known.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.