About canagliflozin
Sodium-glucose cotransporter 2 inhibitor
Used for
- Treats type 2 diabetes alongside diet and exercise.
- Reduces cardiovascular and kidney risks in some adults with type 2 diabetes.
Usual adult dose
Usually 100 mg once daily before the first meal; may increase to 300 mg daily when appropriate and kidney function allows.
Usual dose in children
Not established for routine use in children.
Common side effects
- Genital yeast infections
- Urinary tract infections
- Increased urination
- Dehydration or low blood pressure
Important warnings
- Can cause ketoacidosis, sometimes without very high blood sugar.
- Risk of dehydration and low blood pressure, especially with diuretics or illness.
- May increase risk of serious genital infection and lower-limb amputation.
- Kidney function affects use and dosing.
Pregnancy
Not recommended, particularly during the second and third trimesters, because it may harm fetal kidney development.
Breastfeeding
Not recommended; potential effects on a nursing infant’s kidneys are a concern.
Interactions
- Insulin or sulfonylureas may increase low-blood-sugar risk.
- Diuretics may increase dehydration and low-blood-pressure risk.
- Rifampin and other enzyme inducers may reduce canagliflozin levels.
- Digoxin levels may increase; monitoring may be needed.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.