About caffeine anhydrous + ergotamine tartrate
Ergot alkaloid and caffeine combination
Used for
- Treatment of migraine attacks, usually when simpler pain relievers have not worked.
Usual adult dose
At migraine onset, take 2 tablets; if needed, take 1 every 30 minutes. Maximum 6 tablets per attack and 10 weekly.
Common side effects
- Nausea or vomiting
- Dizziness
- Tingling or numbness
- Muscle pain or weakness
Important warnings
- Do not use for prevention or more often than directed; overuse can cause medication-overuse headaches.
- Avoid with pregnancy, uncontrolled high blood pressure, or circulation, heart, kidney, or liver disease.
- Do not combine with other ergot medicines or strong CYP3A4 inhibitors.
- Seek urgent care for cold, painful, pale or blue fingers or toes.
Pregnancy
Avoid; ergotamine can cause uterine contractions and harm the fetus.
Breastfeeding
Avoid; ergotamine may reduce milk production and can harm a nursing infant.
Interactions
- Triptans and other ergot medicines can cause dangerous blood-vessel narrowing.
- Strong CYP3A4 inhibitors, including clarithromycin and ritonavir, can cause severe toxicity.
- Avoid grapefruit; it may increase ergotamine exposure.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.