About naltrexone hcl + bupropion hcl
Opioid antagonist and aminoketone antidepressant
Used for
- Long-term weight management in adults with obesity or overweight and weight-related conditions, alongside reduced-calorie eating and increased activity.
Usual adult dose
One tablet each morning in week one, increasing weekly to two tablets twice daily from week four. Take with food, but not a high-fat meal.
Common side effects
- Nausea, constipation, headache, vomiting, or dizziness
- Dry mouth, insomnia, or diarrhea
- Increased blood pressure or heart rate
- Seizures, rarely
Important warnings
- Not for uncontrolled high blood pressure, seizure disorders, or current or past eating disorders.
- Do not use with opioids, other bupropion medicines, or monoamine oxidase inhibitors.
- Can cause suicidal thoughts, mood changes, or increased blood pressure.
- Stop and seek urgent help for a seizure or severe allergic reaction.
Pregnancy
Weight-loss treatment is not recommended during pregnancy; discontinue if pregnancy occurs.
Breastfeeding
Not recommended while breastfeeding because both medicines can enter breast milk and may harm an infant.
Interactions
- Opioids, including some pain medicines, cough medicines, and opioid-dependence treatments
- Other bupropion products, monoamine oxidase inhibitors, or medicines lowering seizure threshold
- Medicines affected by CYP2D6, including some antidepressants, antipsychotics, and beta blockers
- Alcohol; sudden heavy drinking or stopping alcohol may increase seizure risk
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.