About bupivacaine + epinephrine
Local anesthetic with vasoconstrictor
Used for
- Local or regional anesthesia for surgery and procedures
- Epinephrine helps prolong anesthesia and reduce bleeding
Usual adult dose
Varies by procedure and injection site; a clinician calculates the lowest effective dose, typically not exceeding 2 mg/kg or 175 mg of bupivacaine.
Usual dose in children
Individualized by weight and procedure; administered by trained clinicians with age-appropriate limits.
Common side effects
- Numbness or tingling
- Dizziness or restlessness
- Low blood pressure or slow heartbeat
- Rarely, seizures or dangerous heart rhythm problems
Important warnings
- For injection by trained clinicians only; accidental injection into a blood vessel can be life-threatening.
- Toxicity may cause ringing ears, metallic taste, seizures, breathing problems, or cardiac arrest.
- Epinephrine may be unsuitable in areas with poor blood supply or certain heart conditions.
- Monitor cardiovascular and respiratory function during administration.
Pregnancy
Use only when clinically needed; anesthetic crosses the placenta, and epinephrine can affect blood flow.
Breastfeeding
Bupivacaine levels in milk are generally low; limited evidence is available for this combination.
Interactions
- Other local anesthetics increase toxicity risk.
- Medicines affecting heart rhythm may increase cardiac risks.
- Some antidepressants and beta-blockers can intensify epinephrine effects.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.